반응 #320823
ord-ed41e9a71f4542799034bed3d12bf60d
반응 방정식
반응 조건
후처리
- 1온도at reflux temperature for 8 hrs
- 2기타the organic solution was evaporated to dryness under reduced pressure
- 3추출The residue was extracted with ethyl acetate
- 4건조the organic layer was dried over anhydrous sodium sulfate
- 5기타evaporated to dryness under reduced pressure
- 6기타The crude product was purified by flash-chromatography
실험 절차
To a solution of 0.40 g of 3β-(3-carbethoxyprop-2-enoxy)-17β-(3-furyl)-5β-androstan-14β-ol in 30 ml of anhydrous tetrahydrofuran, 2 ml of sodium bis(2-methoxyethoxy)aluminum hydride (solution 3.4M in toluene) were added at room temperature. The solution was kept at reflux temperature for 8 hrs, then 10 ml of water were added and the organic solution was evaporated to dryness under reduced pressure. The residue was extracted with ethyl acetate and the organic layer was dried over anhydrous sodium sulfate and evaporated to dryness under reduced pressure. The crude product was purified by flash-chromatography using n-hexane/ethyl acetate 70/30 as eluant to give 0.30 g of 3β-(4-hydroxybutoxy)-17β-(3-furyl)-5β-androstan-14β-ol, as a white pasty solid.