반응 #320784

반응 방정식

2-amino-5-bromo-3-cyano-4-methylpyridine

6-chloro-2,3-dihydro-2,2-dimethylbenzofuran-4-ylboronic acid

potassium carbonate

→

2-amino-3-cyano-4-methyl-5-(6-chloro-2,3-dihydro-2,2-dimethylbenzofuran-4-yl)pyridine

용매

toluene

반응 조건

후처리

1. 1
   기타This compound is prepared in a manner analogous to that of Step D of Example 4

실험 절차

This compound is prepared in a manner analogous to that of Step D of Example 4, using 1.7 grams (0.008 mole) of 2-amino-5-bromo-3-cyano-4-methylpyridine, 2.7 grams (0.012 mole) of 6-chloro-2,3-dihydro-2,2-dimethylbenzofuran-4-ylboronic acid, 4.3 grams (0.031mole) of potassium carbonate and 0.3 mL (catalyst) of tetrakis(triphenylphosphine)palladium(0) in 150 mL of toluene, yielding 2-amino-3-cyano-4-methyl-5-(6-chloro-2,3-dihydro-2,2-dimethylbenzofuran-4-yl)pyridine.

출처