반응 #3207

반응 방정식

2-nitro-4-methoxybenzonitrile

acetic acid

sulfuric acid

→

benzoic acid

수율 91.8%

2-Nitro-4-methoxybenzoic acid

수율 91.8%

용매

water

water

반응 조건

후처리

1. 1
   온도was refluxed for 11 hr
2. 2
   온도to cool
3. 3
   기타The resulting precipitate which formed
4. 4
   기타was collected
5. 5
   세척washed with water
6. 6
   기타dried

실험 절차

A mixture of 2-nitro-4-methoxybenzonitrile (14.0 g, 78.6 mM) in a solution of acetic acid (28 mL), sulfuric acid (28 mL) and water (28 mL) was refluxed for 11 hr, allowed to cool and diluted with water (200 mL). The resulting precipitate which formed was collected, washed with water and dried to give the title benzoic acid (14.2 g, 91.8%) as a yellow crystalline solid; MS(CI): 198 (M+H).

출처