반응 #3199

반응 방정식

4,6-dichloro-1H-indole-2,3-dione

acetic acid

→

title compound

수율 72.0%

5,7-Dichloro-2H-3,1-benzoxazine-2,4(1H)-dione

수율 72.0%

용매

water

acetic anhydride

반응 조건

후처리

1. 1
   workup.ADDITIONAfter the addition
2. 2
   여과filtered
3. 3
   기타to separate the precipitated solids
4. 4
   세척The solids were washed thoroughly with water
5. 5
   기타dried

실험 절차

To a stirred solution of 4,6-dichloro-1H-indole-2,3-dione (5.00 g, 23.2 mM) in acetic acid (21 mL) and acetic anhydride (21 mL) at 80° C. was added in small portions chromium trioxide (4.12 g, 41.3 mM). The temperature of the reaction mixture was maintained between 80°-90° C. during the addition of the chromium trioxide. After the addition was complete, the reaction mixture was diluted with water (100 mL) and then filtered to separate the precipitated solids. The solids were washed thoroughly with water and then dried to obtain the title compound as a yellow solid (4.13 g, 72%); MS(CI): 232 (M+H).

출처