반응 #319533

반응 방정식

5'-amino-2',5'-dideoxy-3'-O-ethyl-5-ethyluridine

(2,6-dichlorophenyl)acetyl chloride

→

5'-[2-(2,6-dichlorophenyl)acetamido]-2',5'-dideoxy-3'-O-ethyl-5-ethyluridine

용매

sodium hydroxide

diethyl ether

반응 조건

후처리

1. 1
   여과filtered
2. 2
   세척The solid was washed with 5 ml of water and 50 ml of diethyl ether
3. 3
   기타recrystallized from acetone

실험 절차

A solution of (2,6-dichlorophenyl)acetyl chloride (prepared from 103 mg of the acid) in 2 ml of diethyl ether was added to a solution of 140 mg of 5'-amino-2',5'-dideoxy-3'-O-ethyl-5-ethyluridine in 2.5 ml of 0.2M sodium hydroxide solution, the mixture was shaken vigorously for 10 minutes and then filtered. The solid was washed with 5 ml of water and 50 ml of diethyl ether, and then recrystallized from acetone to give 60 mg of 5'-[2-(2,6-dichlorophenyl)acetamido]-2',5'-dideoxy-3'-O-ethyl-5-ethyluridine in the form of a white solid of melting point 249°-250° C.

출처