반응 #319531

반응 방정식

5'-amino-3'-O-benzyl-2',5'-dideoxy-5-ethyluridine

(2,6-dichlorophenyl)acetyl chloride

→

3'-O-benzyl-5'-[2-(2,6-dichlorophenyl)acetamido]-2',5'-dideoxy-5-ethyluridine

용매

sodium hydroxide

diethyl ether

반응 조건

후처리

1. 1
   여과filtered
2. 2
   기타The solid was recrystallized from ethanol

실험 절차

A solution of (2,6-dichlorophenyl)acetyl chloride (prepared from 103 mg of the acid) in 2 ml of diethyl ether was added to a solution of 173 mg of 5'-amino-3'-O-benzyl-2',5'-dideoxy-5-ethyluridine in 4.5 ml of 0.11M sodium hydroxide solution. The mixture was shaken vigorously for 10 minutes and then filtered. The solid was recrystallized from ethanol to give 120 mg of 3'-O-benzyl-5'-[2-(2,6-dichlorophenyl)acetamido]-2',5'-dideoxy-5-ethyluridine in the form of a white solid of melting point 174°-177° C.

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