반응 #319527

반응 방정식

(2,6-dichlorophenyl)acetyl chloride

5'-amino-2',5'dideoxy-5-ethyluridine

→

5'-[2-(2,6-dichlorophenyl)acetamido]-2',5'-dideoxy-5-ethyluridine

수율 69.3%

용매

diethyl ether

sodium hydroxide

반응 조건

후처리

1. 1
   여과filtered
2. 2
   세척The solid was washed with 150 ml of water, 20 ml of ethanol and 40 ml of diethyl ether
3. 3
   기타recrystallized from 2.5 l of ethanol

실험 절차

A solution of 1.12 g of (2,6-dichlorophenyl)acetyl chloride in 15 ml of diethyl ether was added to a solution of 1.275 g of 5'-amino-2',5'dideoxy-5-ethyluridine in 15 ml of 0.33M sodium hydroxide solution. The mixture was shaken vigorously for 10 minutes and then filtered. The solid was washed with 150 ml of water, 20 ml of ethanol and 40 ml of diethyl ether, and then recrystallized from 2.5 l of ethanol to give 1.53 g of 5'-[2-(2,6-dichlorophenyl)acetamido]-2',5'-dideoxy-5-ethyluridine in the form of a white solid of melting point 296°-297° C.

출처