반응 #319526

반응 방정식

benzoyl chloride

5'-amino-2',5'-dideoxy-5-ethyluridine

→

5'-benzamido-2',5'-dideoxy-5-ethyluridine

수율 39.1%

용매

sodium hydroxide

반응 조건

후처리

1. 1
   여과The mixture was filtered
2. 2
   세척the solid was washed with 5 ml of water and 5 ml of diethyl ether
3. 3
   기타recrystallized from ethanol

실험 절차

140 mg of benzoyl chloride were added to a solution of 255 mg of 5'-amino-2',5'-dideoxy-5-ethyluridine in 3 ml of 0.33M sodium hydroxide solution and the mixture was shaken vigorously for 5 minutes. The mixture was filtered and the solid was washed with 5 ml of water and 5 ml of diethyl ether, and recrystallized from ethanol to give 140 mg of 5'-benzamido-2',5'-dideoxy-5-ethyluridine of melting point 246°-247° C.

출처