반응 #319135

반응 방정식

4-acetoxybenzoyl chloride

4-cyanothiophenol

pyridine

→

thioester

수율 100.0%

S-(4-Cyanophenyl) 4-(acetoxy)thiobenzoate

수율 100.0%

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   세척the organic solution was washed successively with aqueous 2M hydrochloric acid
2. 2
   기타Evaporation of the extracts, which
3. 3
   건조had been dried over magnesium sulphate

실험 절차

A solution of 4-acetoxybenzoyl chloride (3.33 g) in dry dichloromethane (20 ml) was added over 10 minutes to a cool (5° C.), stirred solution of 4-cyanothiophenol (2.06 g), pyridine (1.45 ml) and 4-N,N-dimethylaminopyridine (25 mg) in dry dichloromethane (30 ml). The stirred solution was allowed to reach room temperature overnight and the organic solution was washed successively with aqueous 2M hydrochloric acid, a saturated sodium bicarbonate solution and water. Evaporation of the extracts, which had been dried over magnesium sulphate, afforded the desired thioester (4.53 g).

출처