반응 #318764
ord-c2b21851377d4ef093985a94dcaa0ab0
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타After removing DMF at 60°
- 2세척the ethyl ester (10.8 g) eluted first with toluene
실험 절차
A solution of 2-amino-6-nitrobenzoic acid (29.2 g, 0.16 mol), diethylsulfate (24.7 g, 0.160 mol) and triethylamine (16.2 g, 0.160 mol) in N-dimethylformamide (250 ml) was stirred at 20-25° for 20 hours. After removing DMF at 60° and 0.2 mm pressure, the residue was flash chromotographed over silica gel and the ethyl ester (10.8 g) eluted first with toluene then with 50% toluene-50% chloroform.