반응 #318025

반응 방정식

4-Fluoro-2-methyl-1-nitrobenzene

sodium benzenesulfinate

→

title compound

수율 75.3%

3-Methyl-4-nitrophenyl phenyl sulphone

수율 75.3%

용매

N,N-dimethylacetamide

반응 조건

후처리

1. 1
   온도After cooling the mixture
2. 2
   여과was filtered
3. 3
   기타the filtrate collected
4. 4
   기타the solvent removed in vacuo
5. 5
   기타The residue was triturated with cyclohexane
6. 6
   여과the resultant precipitate collected by filtration

실험 절차

4-Fluoro-2-methyl-1-nitrobenzene (2.6 g) (available from Aldrich) and sodium benzenesulfinate (3.0 g) (available from Aldrich) were heated in N,N-dimethylacetamide (40 ml) at 50° C. for 16 h. After cooling the mixture was filtered, the filtrate collected and the solvent removed in vacuo. The residue was triturated with cyclohexane and the resultant precipitate collected by filtration to give the title compound as a white solid (3.5 g).

출처