반응 #317593

반응 방정식

5,6-dichloro-2-(2,2,2-trifluoro-ethyl)-1H-benzimidazole

potassium carbonate

3-(bromomethyl)pyridine hydrogen bromide

→

title compound

5,6-Dichloro-1-pyridin-3-ylmethyl-2-(2,2,2-trifluoro-ethyl)-1H-benzoimidazole

용매

DMF

반응 조건

후처리

1. 1
   기타The reaction mixture was quenched with water
2. 2
   추출extracted with EtOAc
3. 3
   건조dried over Na2SO4
4. 4
   기타The crude product was purified by silica gel chromatography (15%-60% EtOAc/hexanes)

실험 절차

To 5,6-dichloro-2-(2,2,2-trifluoro-ethyl)-1H-benzimidazole (423 mg) in DMF (5 mL) was added potassium carbonate powder (868 mg) and 3-(bromomethyl)pyridine hydrogen bromide (615 mg). The resulting mixture was stirred at room temperature overnight. The reaction mixture was quenched with water, extracted with EtOAc, and dried over Na2SO4. The crude product was purified by silica gel chromatography (15%-60% EtOAc/hexanes) to yield the title compound as a green solid.

출처