반응 #316939

반응 방정식

2-thiophencarboxylic acid hydrazide

benzyl isothiocyanate

→

N-benzyl-2-(thien-2-ylcarbonyl)hydrazinecarbothioamide

수율 89.3%

용매

acetonitrile

반응 조건

후처리

1. 1
   기타the reaction vessel was removed from the heat source
2. 2
   여과The resulting crystals were collected by vacuum filtration
3. 3
   세척washed with diethyl ether
4. 4
   기타air-dried

실험 절차

To a hot solution of 2-thiophencarboxylic acid hydrazide (5.0 g, 35 mmol) in acetonitrile (80 mL) was added neat benzyl isothiocyanate (4.7 mL, 35 mmol) via syringe. When the solvent started to boil, the reaction vessel was removed from the heat source and allowed to cool to room temperature. The resulting crystals were collected by vacuum filtration, washed with diethyl ether and air-dried to yield N-benzyl-2-(thien-2-ylcarbonyl)hydrazinecarbothioamide (9.11 g; 89%; (M+H)+−292.2).

출처