반응 #316044

반응 방정식

4-Methoxy-3-methylaniline

Diethyl ethoxymethylenemalonate

→

diethyl 2-[(4-methoxy-3-methyl-phenylamino)-methylene]-malonate

수율 76.0%

용매

isopropanol

반응 조건

후처리

1. 1
   기타to prepare a solution
2. 2
   온도the mixture was heated
3. 3
   온도under reflux for 5 min
4. 4
   온도The reaction solution was cooled
5. 5
   기타the solvent was then removed by distillation under the reduced pressure
6. 6
   세척The residue was washed with ether-hexane

실험 절차

4-Methoxy-3-methylaniline (45.2 g) was dissolved in isopropanol (100 ml) to prepare a solution. Diethyl ethoxymethylenemalonate (71.3 g) was added to the solution, and the mixture was heated under reflux for 5 min. The reaction solution was cooled, and the solvent was then removed by distillation under the reduced pressure. The residue was washed with ether-hexane to give diethyl 2-[(4-methoxy-3-methyl-phenylamino)-methylene]-malonate (76.9 g, yield 76%).

출처