반응 #316039

반응 방정식

hydrochloric acid

Sodium hydroxide

water

5-Fluoro-1H-indole-2,3-dione

2-hydroxy-1-phenyl-ethanone

→

6-fluoro-3-hydroxy-2-phenyl-quinoline-4-carboxylic acid

수율 21.0%

용매

methanol

반응 조건

후처리

1. 1
   기타to prepare a solution
2. 2
   세척the precipitated crystal was washed with methanol and water

실험 절차

5-Fluoro-1H-indole-2,3-dione (1.19 g) and 2-hydroxy-1-phenyl-ethanone (2.25 g) were dissolved in methanol (70 ml) to prepare a solution. Sodium hydroxide (4.82 g) and water (30 ml) were added to the solution, and the mixture was stirred at room temperature overnight. Dilute hydrochloric acid was added to the reaction solution, and the precipitated crystal was washed with methanol and water to give 6-fluoro-3-hydroxy-2-phenyl-quinoline-4-carboxylic acid (427 mg, yield 21%).

출처