반응 #315918

반응 방정식

4-Chloro-6,7-dimethoxyquinoline

2-bromo-3-pyridinol

→

title compound

수율 6.0%

4-(2-Bromo-pyridin-3-yloxy)-6,7-dimethoxyquinoline

수율 6.0%

용매

o-dichlorobenzene

반응 조건

후처리

1. 1
   온도The reaction solution was cooled to room temperature
2. 2
   기타the solvent was then removed by distillation under the reduced pressure
3. 3
   기타the residue was purified by column chromatography

실험 절차

4-Chloro-6,7-dimethoxyquinoline (226 mg), 2-bromo-3-pyridinol (250 mg), and 4-dimethylaminopyridine (400 mg) were suspended in o-dichlorobenzene (10 ml), and the suspension was stirred at 140° C. for 2 hr. The reaction solution was cooled to room temperature, the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using acetone-chloroform to give the title compound (21 mg, yield 6%).

출처