반응 #314285

반응 방정식

8-(3,4-dimethyl-benzoyl)-2,3-dihydro-6H-[1,4]dioxino[2,3-g]quinolin-9-one

sodium hydride

3-bromomethylpyridine hydrobromide

→

8-(3,4-Dimethyl-benzoyl)-6-pyridin-3-ylmethyl-2,3-dihydro-6H-[1,4]dioxino[2,3-g]quinolin-9-one

용매

N,N-dimethylformamide

반응 조건

실험 절차

Experimental conditions analogous to those described for Step 3 of Example 1, from 58 mg (0.17 mmol) of 8-(3,4-dimethyl-benzoyl)-2,3-dihydro-6H-[1,4]dioxino[2,3-g]quinolin-9-one, 18 mg of 60% sodium hydride, 57 mg of 3-bromomethylpyridine hydrobromide and 1.2 mL of N,N-dimethylformamide. Yield: 55 mg of a white solid: LC-MSD, m/z for C26H22N2O4 [M+H]+=427.5; HPLC retention time: 1.6 min.

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