반응 #314282

반응 방정식

7-(3,4-dimethyl-benzoyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one

sodium hydride

3-bromomethylpyridine hydrobromide

→

7-(3,4-Dimethyl-benzoyl)-5-pyridin-3-ylmethyl-5H-[1,3]dioxolo[4,5-g]quinolin-8-one

용매

N,N-dimethylformamide

반응 조건

실험 절차

Experimental conditions analogous to those described for Step 3 of Example 1, from 71 mg (0.22 mmol) of 7-(3,4-dimethyl-benzoyl)-5H-[1,3]dioxolo[4,5-g]quinolin-8-one, 23 mg of 60% sodium hydride, 72 mg of 3-bromomethylpyridine hydrobromide and 1.3 mL of N,N-dimethylformamide. Yield: 45 mg of a white solid: LC-MSD, m/z for C25H20N2O4 [M+H]+=413.5; HPLC retention time: 1.5 min.

출처