반응 #3142
ord-4d14267579d347aaab5da8765031fa8d
반응 방정식
4,6-dihydroxy-2-methylpyrimidinamine
sodium ethoxide
sodium
Acetamidine hydrochloride
diethyl malonate
→
4,6-dihydroxy-2-methylpyrimidine
반응물
시약
없음
용매
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도the reaction mixture heated
실험 절차
The first intermediate, 4,6-dihydroxy-2-methylpyrimidinamine, is synthesized by preparing sodium ethoxide in situ from sodium and an hydrous ethanol under a nitrogen blanket. Acetamidine hydrochloride and diethyl malonate are added and the reaction mixture heated to boiling for 2 to 5 hours to afford 4,6-dihydroxy-2-methylpyrimidine.