반응 #314161

반응 방정식

2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester

4-Methyl-pyridin-3-ylamine

→

3-(3,4-Dimethyl-benzoyl)-8-methyl-1H-[1,5]naphthyridin-4-one

수율 16.1%

용매

diphenyl ether

반응 조건

실험 절차

Experimental conditions analogous to those described for Step 1 of Example 1 were used with 0.50 g (2.01 mmol) 2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester, 0.22 g (2.01 mmol) of 4-Methyl-pyridin-3-ylamine, and 30 mL of diphenyl ether to yield 94.4 mg of 3-(3,4-Dimethyl-benzoyl)-8-methyl-1H-[1,5]naphthyridin-4-one as a brown solid.

출처