반응 #313369

반응 방정식

Benzenesulfonyl chloride

methyl 6-aminohexanoate hydrochloride

sodium carbonate

→

title compound

6-Benzenesulfonylaminohexanoic acid methyl ester

용매

acetonitrile

water

반응 조건

후처리

1. 1
   추출the product was extracted with ethyl acetate (30 ml)
2. 2
   건조The extract was dried (Na2SO4) and solvents
3. 3
   기타were removed under reduced pressure
4. 4
   기타The product was chromatographed on silica gel with ethyl acetate-hexane (1:2) as eluent

실험 절차

Benzenesulfonyl chloride (92a) (0.88 g, 5.0 mmol) was added to the mixture of methyl 6-aminohexanoate hydrochloride (91) (1.82 g, 10 mmol) in acetonitrile (10 ml) and sodium carbonate (2.6 g, 24.6 mmol) in water (10 ml). The mixture was stirred for 6 hours at ambient temperature, and the product was extracted with ethyl acetate (30 ml). The extract was dried (Na2SO4) and solvents were removed under reduced pressure. The product was chromatographed on silica gel with ethyl acetate-hexane (1:2) as eluent. The title compound was obtained as oil (128 g, 90%). 1H NMR δH (90 MHz, DMSO-d6) δ: 0.90-1.63 (6H, m, CH2); 2.21 (2H, t, J=7.0 Hz, CH2); 2.71 (2H, q, J=6.0 Hz, CH2N); 3.58 (3H, s, CH3); 7.40-7.72 (3H, m, C6H3); 7.72-7.89 (2H, m, C6H2).

출처