반응 #312633

반응 방정식

1-Hydroxy-cyclopropanecarboxylic acid methyl ester

tetrahydrofuran

Sodium hydride

→

title product

1-Methoxy-cyclopropanecarboxylic acid methyl ester

반응 조건

후처리

1. 1
   기타The reaction mixture was quenched with ammonium chloride
2. 2
   추출extracted with ethylacetate

실험 절차

1-Hydroxy-cyclopropanecarboxylic acid methyl ester (1.1 6 gm, 10 mmol) was dissolved in 10 ml of tetrahydrofuran and cooled under a nitrogen atmosphere to 0° C. Sodium hydride (0.52 gm, 60% oil dispersion) was added portionwise followed by lodomethane (1 ml) and stirred for 18 hrs. The reaction mixture was quenched with ammonium chloride and extracted with ethylacetate to obtain 2 gm of title product. (MH+=130)

출처