반응 #312489

반응 방정식

formaldehyde

formalin

4-Hydroxybenzeneacetic acid

hydrochloric acid

→

title compound

3-Chloromethyl-4-hydroxybenzeneacetic acid

반응 조건

후처리

1. 1
   기타Hydrogen chloride is bubbled through the reaction mixture for 60 minutes
2. 2
   온도while maintaining the temperature of the reaction mixture at 35° to 45° C
3. 3
   workup.ADDITIONThe reaction mixture is poured into water
4. 4
   추출the title compound is extracted from the solution with ethyl acetate
5. 5
   건조The ethyl acetate is dried over magnesium sulfate
6. 6
   여과filtered
7. 7
   기타removed

실험 절차

4-Hydroxybenzeneacetic acid, 0.5 mole, is added to concentrated hydrochloric acid, 50 ml, then 0.5 mole of formaldehyde in the form of a 34-38% solution of formalin is added. Hydrogen chloride is bubbled through the reaction mixture for 60 minutes while maintaining the temperature of the reaction mixture at 35° to 45° C. The reaction mixture is poured into water and the title compound is extracted from the solution with ethyl acetate. The ethyl acetate is dried over magnesium sulfate, filtered and removed to give the title compound.

출처