반응 #312442

반응 방정식

4-(α,α,α-trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carboxylic acid

diborane

→

8-Methyl-4-(α,α,α-trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine

용매

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   온도chilled in an ice bath
2. 2
   workup.ADDITIONThe mixture is poured onto ice
3. 3
   추출extracted with methylene chloride
4. 4
   추출The methylene chloride extract
5. 5
   세척is washed with water
6. 6
   건조dried (MgSO4)
7. 7
   기타The solvent is removed under reduced pressure
8. 8
   기타to give the product of the example

실험 절차

A solution of 0.010 mole of 4-(α,α,α-trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carboxylic acid in tetrahydrofuran is added dropwise to a 0.02 molar solution of diborane in tetrahydrofuran chilled in an ice bath. The mixture is allowed to warm to room temperature and stand overnight. The mixture is poured onto ice and extracted with methylene chloride. The methylene chloride extract is washed with water and dried (MgSO4). The solvent is removed under reduced pressure to give the product of the example.

출처