반응 #312186

반응 방정식

2-(3-hydroxyphenoxy)-3-chloro-5-trifluoromethyl pyridine

bromine

→

2-(3-hydroxy-4-bromophenoxy)-3-chloro-5-trifluoromethyl pyridine

수율 42.9%

용매

chloroform

반응 조건

후처리

1. 1
   기타After the reaction
2. 2
   세척the reaction product was washed with water, with a sodium bicarbonate aqueous solution, with a saturated sodium thiosulfate solution
3. 3
   건조with water and dried over anhydrous sodium sulfate
4. 4
   workup.DISTILLATIONChloroform was distilled off under a reduced pressure
5. 5
   세척the resulting crystals were washed with hexane
6. 6
   기타dried

실험 절차

In 150 ml of chloroform, 5.5 g of 2-(3-hydroxyphenoxy)-3-chloro-5-trifluoromethyl pyridine was dissolved and then, 3.5 g of bromine was added dropwise to the solution at a temperature of 10° to 15° C. After the reaction, the reaction product was washed with water, with a sodium bicarbonate aqueous solution, with a saturated sodium thiosulfate solution and then, with water and dried over anhydrous sodium sulfate. Chloroform was distilled off under a reduced pressure and the resulting crystals were washed with hexane and dried to obtain 3.0 g of 2-(3-hydroxy-4-bromophenoxy)-3-chloro-5-trifluoromethyl pyridine having a melting point of 124° to 127° C.

출처