반응 #311918

반응 방정식

(S)-2,2,4-trimethyl-1,3-dioxolan-4-ethanol

pyridine chlorochromate

ether

→

(S)-2,2,4-trimethyl-1,3-dioxolan-4-acetaldehyde

수율 70.2%

용매

methylene chloride

methylene chloride

반응 조건

후처리

1. 1
   기타the chromium salt was precipitated
2. 2
   기타separated by filtration over 120 g of Kieselgel
3. 3
   기타After removal of the solvent
4. 4
   기타on a rotary evaporator and distillation of the residue at 90°-100°/10 mmHg

실험 절차

4.33 g of (S)-2,2,4-trimethyl-1,3-dioxolan-4-ethanol dissolved in 7 ml of absolute methylene chloride were added dropwise to a suspension of 7.59 g of pyridine chlorochromate in 30 ml of absolute methylene chloride. The reaction mixture was stirred at room temperature for 3 hours. By addition of 75 ml of ether, the chromium salt was precipitated and separated by filtration over 120 g of Kieselgel. After removal of the solvent on a rotary evaporator and distillation of the residue at 90°-100°/10 mmHg, there were obtained 3.00 g of (S)-2,2,4-trimethyl-1,3-dioxolan-4-acetaldehyde. [α]D20 =-35.5° (c=1.50; n-hexane).

출처