반응 #311625

반응 방정식

2-phenyl-1H-imidazole

1-bromo-4-methoxybenzene

potassium carbonate

→

1-(4-methoxyphenyl)-2-phenyl-1H-imidazole

수율 25.0%

용매

N,N-dimethylacetamide

반응 조건

후처리

1. 1
   온도at reflux temperature
2. 2
   온도The reaction mixture is cooled
3. 3
   workup.ADDITIONpoured onto water
4. 4
   추출the product is extracted twice with 2,2'-oxybispropane
5. 5
   기타The combined extracts are dried
6. 6
   여과filtered
7. 7
   기타evaporated

실험 절차

A mixture of 28.8 parts of 2-phenyl-1H-imidazole, 37.4 parts of 1-bromo-4-methoxybenzene, 20 parts of potassium carbonate and 180 parts of N,N-dimethylacetamide is stirred for one week at reflux temperature. The reaction mixture is cooled, poured onto water and the product is extracted twice with 2,2'-oxybispropane. The combined extracts are dried, filtered and evaporated, yielding 10 parts (25%) of 1-(4-methoxyphenyl)-2-phenyl-1H-imidazole as a residue.

출처