반응 #3106

반응 방정식

racemic inden-1-ol

vinyl acetate

→

(R)-1-acetoxyindene

수율 38.0%

(S)-inden-1-ol

수율 10.0%

용매

t-butylmethyl ether

반응 조건

후처리

1. 1
   기타After the end of the reaction
2. 2
   여과the suspension was filtered off
3. 3
   기타to remove lipase
4. 4
   농축The filtrate was concentrated

실험 절차

100 mg (0.76 mmol) of racemic inden-1-ol, 0.13 mg (1.15 mmol) of vinyl acetate and 75.6 mg (100 mg of racemate/mmol) of lipase PS were suspended in 10 ml of t-butylmethyl ether and stirred at 37° C. for 7 days. After the end of the reaction, the suspension was filtered off to remove lipase. The filtrate was concentrated and the residue was subjected to silica gel column chromatography (eluate: ethyl acetate-hexane, 1:10 V/V), to separate into 50 mg (yield 38.0%, optical purity 22% ee) of (R)-1-acetoxyindene and 10 mg (yield 10.0%, optical yield 22% ee) of (S)-inden-1-ol respectively. The optical purities were determined by an analysis according to high speed liquid chromatography (column: chiral cell OD, eluate: isopropanol-hexane, 1% V/V).

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