반응 #310546

반응 방정식

4-hydroxy-6-methyl-2-trichloromethylpyrimidine

triethylamine

ether

isopropyl chloroformate

→

product

수율 58.9%

4-Isopropoxycarbonyloxy-6-Methyl-2-Trichloromethylpyrimidine

수율 58.9%

용매

benzene

반응 조건

후처리

1. 1
   온도The reaction mixture was refluxed one hour
2. 2
   여과filtered
3. 3
   기타rotary evaporated
4. 4
   기타to give a yellow oil
5. 5
   workup.DISTILLATIONThe oil was distilled (bp1.2 mm 120° C.)
6. 6
   기타to give a cloudy yellow oil
7. 7
   여과filtered
8. 8
   기타the solvent removed

실험 절차

To a solution of 3.0 g (0.013 mole) 4-hydroxy-6-methyl-2-trichloromethylpyrimidine, 1.4 g (0.013 mole) triethylamine, and 75 ml ether was added 1.6 g (0.013 mole) isopropyl chloroformate. The reaction mixture was refluxed one hour, filtered, and rotary evaporated to give a yellow oil. The oil was distilled (bp1.2 mm 120° C.) to give a cloudy yellow oil. This was taken up in benzene, filtered, and the solvent removed leaving 2.4 g (57% yield) of product. The structure was confirmed via infrared and elemental analysis.

출처