반응 #310431

반응 방정식

stearylamine

benzoyl chloride

hydrogen chloride

→

crystals

수율 83.0%

N-stearylbenzamide

수율 83.0%

용매

toluene

반응 조건

후처리

1. 1
   기타An exothermic reaction
2. 2
   온도The reaction mixture was heated to 100° C.
3. 3
   기타was terminated
4. 4
   온도The reaction mixture was cooled, from which white crude crystals
5. 5
   기타were separated
6. 6
   기타were then recrystallized from alcohol
7. 7
   기타This recrystallization

실험 절차

27 g of stearylamine was dispersed in 100 ml of toluene. To this dispersion was added 13 g of benzoyl chloride at 70° C. An exothermic reaction occurred and the temperature of the mixture increased to 80° C. The reaction mixture was heated to 100° C. and that temperature was maintained for about 20 hours until generation of hydrogen chloride gas was terminated. The reaction mixture was cooled, from which white crude crystals were separated. The thus obtained white crystals were neutralized with sodium hydroxide and were then recrystallized from alcohol. This recrystallization gave white crystals melting at 85° C. to 87° C. The yield was 83%.

출처