반응 #309101

반응 방정식

sodium hydrogen carbonate

2-methoxypropene

(2-Bromo-5-fluoro-4-hydroxymethylphenyl)-methanol

tetrahydrofuran

→

titled compound

수율 97.0%

1-bromo-4-fluoro-2,5-bis-(1-methoxy-1-methyl-ethoxymethyl)-benzene

수율 97.0%

반응 조건

후처리

1. 1
   추출The resultant mixture was extracted with ethyl acetate
2. 2
   건조The organic layer was dried over anhydrous sodium sulfate
3. 3
   농축concentrated under reduced pressure

실험 절차

(2-Bromo-5-fluoro-4-hydroxymethylphenyl)-methanol (71.3 mg, 0.303 mmol) was dissolved in tetrahydrofuran (1 mL), and 2-methoxypropene (214.7 mg, 2.97 mmol) was added thereto. The resultant mixture was cooled to 0° C., and then p-toluenesulfonic acid (1.0 mg. 0.0029 mmol) was added thereto. This mixture was stirred for 40 minutes, and then saturated aqueous sodium hydrogen carbonate was added. The resultant mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and then concentrated under reduced pressure, to thereby obtain the titled compound (111.7 mg, 97%).

출처