반응 #309060

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5-tert-butyl-2-(4-nitro-phenyl)-2H-pyrazol-3-ylamine

ethyl(4-hydrazinophenyl)acetate hydrochloride

→

HCl

title compound

ethyl[4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl]acetate hydrochloride

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후처리

1. 1
   기타The title compound was prepared in the same manner

실험 절차

The title compound was prepared in the same manner as described for 5-tert-butyl-2-(4-nitro-phenyl)-2H-pyrazol-3-ylamine, replacing 4-nitrophenylhydrazine with ethyl(4-hydrazinophenyl)acetate hydrochloride (11.98 g, 51.9 mmol). The title compound was obtained as a white solid (HCl salt, 11.95 g) in 68% yield. 1H-NMR (DMSO-d6) δ 7.52 (d, J=8.4 Hz, 2H), 7.45 (d, J=8.1 Hz, 2H), 5.59 (s, 1H), 4.08 (q, J=7.1 Hz, 2H), 3.77 (s, 2H), 1.27 (s, 9H), 1.20 (t, J=7.1 Hz, 3H); MS LC-MS [M+H]+=302.3, RT=2.44 min.

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