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3-nitro[1,5]naphthyridin-4-amine

3-nitroquinolin-4-amine

quinoline-3,4-diamine

[1,5]naphthyridine-3,4-diamine

→

1H-imidazo[4,5-c]quinoline

1H-imidazo[4,5-c][1,5]naphthyridine

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실험 절차

In steps (2) and (3) of Reaction Scheme II, a 3-nitroquinolin-4-amine or 3-nitro[1,5]naphthyridin-4-amine of Formula XXVI is first reduced to a quinoline-3,4-diamine or [1,5]naphthyridine-3,4-diamine of Formula XXVII, which is then treated with a halogen-substituted carboxylic acid equivalent to provide a 1H-imidazo[4,5-c]quinoline or 1H-imidazo[4,5-c][1,5]naphthyridine of Formula XXVIII. Steps (2) and (3) of Reaction Scheme II can be carried out according to the methods described in steps (3) and (4) of Reaction Scheme I.

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