반응 #3083

반응 방정식

2-(4-aminophenoxy)-2-methyl propionic acid

chloroform

sodium hydroxide

p-acetamidophenol

acetone

→

2-(4-acetaminophenoxy)-2-methyl propionic acid

수율 60.0%

반응 조건

후처리

1. 1
   기타a reaction scheme
2. 2
   기타a compound that is useful as a precursor in the preparation of Group I compounds
3. 3
   workup.STIRRINGThe reaction mixture is stirred overnight at room temperature
4. 4
   기타acetone is removed under vacuum
5. 5
   workup.DISSOLUTIONThe residue is dissolved in water (10 ml)

실험 절차

FIG. 2A illustrates a reaction scheme for preparing 2-(4-aminophenoxy)-2-methyl propionic acid, a compound that is useful as a precursor in the preparation of Group I compounds. In accordance with the scheme of FIG. 2A, 8 grams (g) (0.2 mol) of pulverized sodium hydroxide is added to a suspension of 5.28 g (0.035 mol) of p-acetamidophenol in 23 ml (0.4 mol) of acetone. The reaction mixture is stirred at room temperature for 1/2 hour. Subsequently, 3.58 g (0.03 mol) of chloroform is added dropwise over the course of 30 minutes. The reaction mixture is stirred overnight at room temperature and acetone is removed under vacuum. The residue is dissolved in water (10 ml), followed by acidification with 37% hydrochloric acid (HCl) to produce a pale yellow precipitate of 2-(4-acetaminophenoxy)-2-methyl propionic acid (5 g, 60% yield), crystallized from methanol, mp 69°-71° C.

출처