반응 #3064

ord-2f2ad81b1f6b433ea7c984999ad32978

반응 방정식

COC(=O)[C@@H](N)Cc1ccccc1.Cl
phenylalanine methyl ester hydrochloride
CCN(CC)CC
triethylamine
O=CO
formic acid
CC(=O)OC(C)=O
acetic anhydride
COC(=O)[C@H](Cc1ccccc1)NC=O
N-formylphenylalanine methyl ester

용매

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

To a mixture of 1 mmol of phenylalanine methyl ester hydrochloride and 2 mmol of triethylamine in 1 mL of DMF at 0 ° C. was added 2 mL of formic acid and 0.7 mL of acetic anhydride. After stirring for 16 h at rt, extractive isolation provided N-formylphenylalanine methyl ester.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05731432uspto-grants-1998_03