반응 #305268

반응 방정식

4-(2-Bromo-2-fluoro-acetyl)-benzoic acid methyl ester

4-methyl-piperazine-1-carbothioic acid amide

→

title compound

수율 74.0%

4-[5-Fluoro-2-(4-methyl-piperazin-1-yl)-thiazol-4-yl]-benzoic acid methyl ester

수율 74.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도The reaction was heated
2. 2
   온도at reflux for 2 h
3. 3
   기타to precipitate
4. 4
   여과The product was collected by filtration
5. 5
   세척washed with cold ethanol

실험 절차

4-(2-Bromo-2-fluoro-acetyl)-benzoic acid methyl ester (1.18 mmol) and 4-methyl-piperazine-1-carbothioic acid amide (1.18 mmol) were dissolved in ethanol (10 mL). The reaction was heated at reflux for 2 h. The reaction was cooled to RT causing the product to precipitate. The product was collected by filtration and washed with cold ethanol. The product was given an aqueous sodium bicarbonate work up to yield the title compound as a colourless oil (74%). MS (ES+) 337 (M+H, 100%).

출처