반응 #305065

반응 방정식

(+/−)2-(2-methoxy-3,4,5,6-tetrahydropyridin-3-yl)-1H-isoindole-1,3(2H)-dione

ammonium chloride

→

pure product

수율 95.0%

(+/−)2-(2-Amino-3,4,5,6-tetrahydropyridin-3-yl)-1H-isoindole-1,3(2H)-dione hydrochloride

수율 95.0%

용매

methanol

반응 조건

후처리

1. 1
   온도under reflux for 12 h
2. 2
   기타The cooled solution was evaporated
3. 3
   기타to remove solvent
4. 4
   기타The residue was triturated with diethyl ether
5. 5
   여과filtered

실험 절차

To a solution of 23.224 g (89.92 mMol) of (+/−)2-(2-methoxy-3,4,5,6-tetrahydropyridin-3-yl)-1H-isoindole-1,3(2H)-dione dissolved in 409 mL of methanol was added at room temperature 4.81 g (89.92 mmol) of ammonium chloride. The resulting mixture was stirred under reflux for 12 h. The cooled solution was evaporated to remove solvent. The residue was triturated with diethyl ether and filtered to afford 23.8 g (95%) of the pure product as a white powder.

출처