반응 #305064

반응 방정식

sodium hydrogen carbonate

trimethyloxonium tetrafluoroborate

(+/−)-3-phtalimidopiperidin-2-one

→

pure product

수율 99.0%

(+/−)2-(2-Methoxy-3,4,5,6-tetrahydropyridin-3-yl)-1H-isoindole-1,3(2H)-dione

수율 99.0%

용매

dichloromethane

반응 조건

후처리

1. 1
   추출extracted with dichloromethane
2. 2
   건조dried over sodium sulfate
3. 3
   기타the solvent was evaporated

실험 절차

To a solution of 13.474 g (91.1 mmol) of trimethyloxonium tetrafluoroborate in 294 mL of anhydrous dichloromethane was added 22.25 g (91.1 mmol) of (+/−)-3-phtalimidopiperidin-2-one (Heterocycles (1996), 42(2), 537-42, Enantiomer (2001), 6(5), 275-279, Synthesis (1991), (5), 417-20) and the resulting mixture was stirred at room temperature for 12 h. The mixture was hydrolyzed with a saturated aqueous solution of sodium hydrogen carbonate, extracted with dichloromethane, dried over sodium sulfate and the solvent was evaporated to afford 23.22 g (99%) of pure product as a yellow oil. The compound was used as such in the next step.

출처