반응 #304950
ord-7df822b9d62d4de1af2f7511b62d0731
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출The reaction mixture was extracted with dichloromethane
- 2세척washed with water (×3)
- 3건조The combined organic layer was dried over anhydrous MgSO4
- 4여과filtered
- 5농축concentrated in vacuo
- 6기타The crude product was purified by column chromatography with PE
실험 절차
To a solution of the product of step (i) (32.25 g, 0.15 mol) in anhydrous dichloromethane (400 mL) was added triethylamine (45 g, 0.45 mol), DMAP (915 mg, 7.5 mmol) and TBSCl (33 g, 0.215 mol) sequentially. The resulting solution was stirred overnight. The reaction mixture was extracted with dichloromethane and washed with water (×3). The combined organic layer was dried over anhydrous MgSO4, filtered and concentrated in vacuo. The crude product was purified by column chromatography with PE to afford the subtitle compound (ii) as a pale brown oil (40 g).