반응 #3049

반응 방정식

Water

Allyl bromide

2-t-butylphenol

potassium carbonate

→

2-(1,1-dimethylethyl)phenoxypropene

용매

acetone

반응 조건

후처리

1. 1
   온도at reflux temperature for 50 hours
2. 2
   기타the resulting layers were separated
3. 3
   추출The aqueous layer was extracted with 600 ml of diethyl ether
4. 4
   추출extract
5. 5
   건조the resulting solution was dried over sodium sulfate overnight
6. 6
   기타After sodium sulfate removal
7. 7
   기타the solvent was evaporated
8. 8
   기타to provide

실험 절차

Allyl bromide (69.2 ml), 2-t-butylphenol (122.9 ml) and potassium carbonate (121.6 g) were stirred in 265 ml of acetone at reflux temperature for 50 hours and then cooled to 35° C. Water (600 ml) was added and the resulting layers were separated. The aqueous layer was extracted with 600 ml of diethyl ether. The organic layer was combined with the aqueous layer's ether extract and the resulting solution was dried over sodium sulfate overnight. After sodium sulfate removal, the solvent was evaporated to provide, after further workup, 147 g of the subtitled intermediate.

출처