반응 #304734

반응 방정식

CHCl3 MeOH

NaOH Methanol

acetic acid 2-(2-{2-[2-(2,2-dimethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethyl ester

Compound 4

acetic acid 2-(2-{2-[2-(2,2-dimethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethyl ester

→

product

수율 76.0%

2-(2-{2-[2-(2,2-Dimethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol

수율 76.0%

용매

methanol

반응 조건

후처리

1. 1
   기타The solvent was evaporated
2. 2
   기타the residue purified by flash chromatography (CHCl3/MeOH, 9:1)

실험 절차

1 N NaOH/Methanol (1 ml) was added to a stirring solution of acetic acid 2-(2-{2-[2-(2,2-dimethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethyl ester (Compound 4) (110 mg, 0.34 mmol) in methanol (3 ml) at ambient temperature. The reaction was monitored by TLC (CHCl3/MeOH, 9:1) and was completed within 30 minutes. The solvent was evaporated and the residue purified by flash chromatography (CHCl3/MeOH, 9:1) to afford the product (73 mg, 76%) as a colourless oil.

출처