반응 #304532

ord-17b1a6ea7f8a4894b129041d490fcc6d

반응 방정식

COCC(C)NC(=O)c1cc(-c2ccc(C)cc2)cc(-n2nnnc2C(F)(F)F)c1
4′-Methyl-5-(5-trifluoromethyl-tetrazol-1-yl)-biphenyl-3-carboxylic acid (2-methoxy-1-methyl-ethyl)-amide
COCC(C)N
2-methoxy-1-methyl-ethylamine
→
Cc1ccc(-c2cc(C(=O)O)cc(-n3nnnc3C(F)(F)F)c2)cc1
4′-methyl-5-(5-trifluoromethyl-tetrazol-1-yl)-biphenyl-3-carboxylic acid

반응물

COCC(C)NC(=O)c1cc(-c2ccc(C)cc2)cc(-n2nnnc2C(F)(F)F)c1
4′-Methyl-5-(5-trifluoromethyl-tetrazol-1-yl)-biphenyl-3-carboxylic acid (2-methoxy-1-methyl-ethyl)-amide
COCC(C)N
2-methoxy-1-methyl-ethylamine

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

4′-Methyl-5-(5-trifluoromethyl-tetrazol-1-yl)-biphenyl-3-carboxylic acid (2-methoxy-1-methyl-ethyl)-amide was reacted with 2-methoxy-1-methyl-ethylamine using the procedure of step 4 of Example 3 to give 4′-methyl-5-(5-trifluoromethyl-tetrazol-1-yl)-biphenyl-3-carboxylic acid. MS (M+H)=420.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08193368B2uspto-grants-2012_06