반응 #304530

반응 방정식

NaN3

5-[1-chloro-2,2,2-trifluoro-eth-(Z)-ylideneamino]-4′-methyl-biphenyl-3-carboxylic acid methyl ester

→

4′-methyl-5-(5-trifluoromethyl-tetrazol-1-yl)-biphenyl-3-carboxylic acid methyl ester

수율 100.0%

용매

ACN

반응 조건

후처리

1. 1
   workup.ADDITIONThe reaction mixture were poured into ice-cold aqueous Na2CO3 solution
2. 2
   추출extracted with ethyl acetate
3. 3
   세척The organic layer washed with brine
4. 4
   건조dried over anhydrous Na2SO4
5. 5
   여과filtered
6. 6
   농축concentrated in vacuo

실험 절차

A mixture of NaN3 (481 mg, 7.4 mmol) and 5-[1-chloro-2,2,2-trifluoro-eth-(Z)-ylideneamino]-4′-methyl-biphenyl-3-carboxylic acid methyl ester (1.3 g, 3.7 mmol) in 10 ml of dry ACN was stirred at room temperature for 16 hours. The reaction mixture were poured into ice-cold aqueous Na2CO3 solution, extracted with ethyl acetate. The organic layer washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated in vacuo. The resulting crude 4′-methyl-5-(5-trifluoromethyl-tetrazol-1-yl)-biphenyl-3-carboxylic acid methyl ester (1.34 g, 99% yield) was used directly in the next step.

출처