반응 #303789

반응 방정식

Triethylamine

ethyl 2-bromo-2,2-difluoroacetate

4-(2-mercapto-1H-imidazol-1-yl)-1-naphthonitrile

→

ethyl 2-(1-(4-cyanonaphthalen-1-yl)-1H-imidazol-2-ylthio)-2,2-difluoroacetate

용매

dichloromethane

반응 조건

후처리

1. 1
   기타prepared
2. 2
   세척The mixture was washed with aqueous HCl solution (0.2M), 50% saturated sodium chloride solution
3. 3
   건조dried over sodium sulfate
4. 4
   여과filtered
5. 5
   농축concentrated
6. 6
   workup.ADDITIONHexanes were added
7. 7
   농축the mixture concentrated

실험 절차

Triethylamine (1.1 eq), followed by ethyl 2-bromo-2,2-difluoroacetate (1.05 eq) were added to a stirring slurry of 4-(2-mercapto-1H-imidazol-1-yl)-1-naphthonitrile (prepared as described herein, 1 eq) in dichloromethane and stirring continued for 3 h. The mixture was washed with aqueous HCl solution (0.2M), 50% saturated sodium chloride solution, dried over sodium sulfate, filtered, and concentrated. Hexanes were added and the mixture concentrated to provide ethyl 2-(1-(4-cyanonaphthalen-1-yl)-1H-imidazol-2-ylthio)-2,2-difluoroacetate.

출처