반응 #303434

반응 방정식

2-(2,3-dihydro-benzofuran-2-ylmethyl)-isoindole-1,3-dione

hydrazine

→

C-(2,3-dihydro-benzofuran-2-yl)-methylamine

용매

MeOH

CH2Cl2

반응 조건

후처리

1. 1
   여과the mixture is filtered off
2. 2
   농축the filtrate is concentrated
3. 3
   workup.ADDITIONThe residue is diluted with water (50 mL)
4. 4
   추출extracted with CH2Cl2 (2×50 mL)
5. 5
   건조The extracts are dried (MgSO4)
6. 6
   여과filtered
7. 7
   농축concentrated

실험 절차

To a solution of 2-(2,3-dihydro-benzofuran-2-ylmethyl)-isoindole-1,3-dione (0.97 g, 3.47 mmol) in MeOH (15 mL) and CH2Cl2 (5 mL) is added hydrazine (0.55 mL, 17.4 mmol). After 20 h at rt, the mixture is filtered off and the filtrate is concentrated. The residue is diluted with water (50 mL), and extracted with CH2Cl2 (2×50 mL). The extracts are dried (MgSO4), filtered, and concentrated to afford C-(2,3-dihydro-benzofuran-2-yl)-methylamine, which is used for a next step without further purification. LCMS: RT=1.25 minutes; MS: 150 (M+H).

출처