반응 #3030

반응 방정식

2-Trifluoromethyl-4-nitro-benzeneamine

3-trifluoromethylbenzeneamine

potassium carbonate

sodium nitrite

→

4-(3'-trifluoromethyl-4'-nitrophenyl)azobenzeneamine

용매

hydrochloric acid

hydrochloric acid

반응 조건

후처리

1. 1
   기타The resulting solid was recrystallized from THF-ethanol (1:1)

실험 절차

2-Trifluoromethyl-4-nitro-benzeneamine (4.92 g, 23.8 mmol) slurried in 5N hydrochloric acid (15.8 mL) and ice (16 g) was diazotized with 2M sodium nitrite (12.6 mL, 25 mmol) at 0°-5° C., followed by coupling with 3-trifluoromethylbenzeneamine (5.0 g, 31 mmol) in 5N hydrochloric acid (8 mL) at 0°-5° C. The mixture was stirred occasionally for 0.5 h, basified with 25 wt % aqueous potassium carbonate. The resulting solid was recrystallized from THF-ethanol (1:1) to give 4-(3'-trifluoromethyl-4'-nitrophenyl)azobenzeneamine: 1.8 g; mp 144.0°-145.5° C.

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