반응 #302862

ord-e4a4856015b747faa4a7eb10e50a9f34

반응 방정식

CCCCCCCCCCCCCCCC(=O)C(O)C(O)C(O)C(=O)CCCCCCCCCCCCCCC.O=C(O)CCC(=O)O
dipalmitoylglycerol succinate
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole
NCCc1c[nH]cn1
histamine
→
CCCCCCCCCCCCCCCC(=O)C(O)C(O)C(O)C(=O)CCCCCCCCCCCCCCC.NCCc1c[nH]cn1.O=C(O)CCC(=O)O
histamine dipalmitoylglycerol succinate

반응물

CCCCCCCCCCCCCCCC(=O)C(O)C(O)C(O)C(=O)CCCCCCCCCCCCCCC.O=C(O)CCC(=O)O
dipalmitoylglycerol succinate
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole
NCCc1c[nH]cn1
histamine

시약

없음

용매

CN(C)C=O
DMF
CN(C)C=O
DMF

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    workup.STIRRINGThe mixture is stirred overnight
  2. 2
    농축concentrated thoroughly in vacuum
  3. 3
    기타The residue is purified

실험 절차

1.7 g of dipalmitoylglycerol succinate is dissolved in 20 ml of DMF at room temperature. The solution is added with 400 mg of carbonyldiimidazole dissolved in 20 ml of DMF. The mixture is allowed to stir for 1 hour and subsequently added with 300 mg of histamine. The mixture is stirred overnight and concentrated thoroughly in vacuum. The residue is purified using column chromatography on silica gel 60, with chloroform/methanol 10:1 being used as eluant.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08192753B2uspto-grants-2012_06