반응 #302857

반응 방정식

5′-methoxy-2′-hydroxyacetophenone

4-nitrobenzoyl chloride

hydrochloric acid

→

compound 21

4-nitrobenzoic acid 2-acetyl-4-methoxyphenyl ester

용매

pyridine

반응 조건

후처리

1. 1
   기타The obtained mixture was reacted at room temperature for 30 minutes
2. 2
   온도under cooling on ice
3. 3
   여과The obtained precipitate was collected by filtration
4. 4
   세척the filtrate was then washed with purified water

실험 절차

5′-methoxy-2′-hydroxyacetophenone (1.5 g, 9.03 mmol) was added to a pyridine solution (20 ml) that contained 4-nitrobenzoyl chloride (1.72 g, 9.26 mmol) in an ice bath. The obtained mixture was reacted at room temperature for 30 minutes, and the reaction solution was then poured into 1 N hydrochloric acid under cooling on ice. The obtained mixture was intensively stirred. The obtained precipitate was collected by filtration, and the filtrate was then washed with purified water, so as to obtain a product of interest, 4-nitrobenzoic acid 2-acetyl-4-methoxyphenyl ester (compound 21). Yield: 2.49 g (yield constant: 87.4%)

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