반응 #302853

반응 방정식

hydrochloric acid

5′-bromo-2′-hydroxyacetophenone

compound 12

5′-bromo-2′-hydroxyacetophenone

4-methoxybenzoyl chloride

→

compound 13

4-methoxybenzoic acid 2-acetyl-4-bromophenyl ester

용매

pyridine

반응 조건

후처리

1. 1
   기타The obtained mixture was reacted at room temperature for 30 minutes
2. 2
   온도under cooling on ice
3. 3
   여과The obtained precipitate was collected by filtration
4. 4
   세척the filtrate was then washed with purified water

실험 절차

5′-bromo-2′-hydroxyacetophenone (compound 12) (1.80 g, 10.6 mmol) was added to a pyridine solution (40 ml) that contained 4-methoxybenzoyl chloride (2.01 g, 9.35 mmol) in an ice bath. The obtained mixture was reacted at room temperature for 30 minutes, and the reaction solution was then poured into 1 N hydrochloric acid under cooling on ice. The obtained mixture was intensively stirred. The obtained precipitate was collected by filtration, and the filtrate was then washed with purified water, so as to obtain a product of interest, 4-methoxybenzoic acid 2-acetyl-4-bromophenyl ester (compound 13). Yield: 3.15 g (yield constant: 96.5%) 1H NMR (300 MHz, CDCl3) δ 7.72 (d, J=7.5 Hz, 1H), 8.06 (d, J=7.2 Hz, 1H), 8.86 (s, 1H), 10.13 (s, 1H).

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