반응 #2997

반응 방정식

(E)-3-(3-nitro-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-prop-2-ene-nitrile

→

intended compound

수율 99.5%

(E)-3-(3-amino-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-prop-2-ene-nitrile

수율 99.5%

용매

acetic acid

반응 조건

후처리

1. 1
   기타The reaction liquid
2. 2
   여과was filtered
3. 3
   농축concentrated
4. 4
   기타The concentrated liquid was purified by silica gel column chromatography (ethyl acetate:hexane--1.2 by volume)

실험 절차

500 mg of (E)-3-(3-nitro-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-prop-2-ene-nitrile were dissolved in 25 ml of acetic acid, and 5 g of zinc were added thereto and stirred for 30 minutes at room temperature. The reaction liquid was filtered and then concentrated. The concentrated liquid was purified by silica gel column chromatography (ethyl acetate:hexane--1.2 by volume) to obtain 457 mg of the intended compound. The yield was 99%.

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